肝硬化和梗阻性黄疸中的内毒素血症与肾衰竭
Endotoxaemia and renal failure in cirrhosis and obstructive jaundice.
作者信息
Wilkinson S P, Moodie H, Stamatakis J D, Kakkar V V, Williams R
出版信息
Br Med J. 1976 Dec 11;2(6049):1415-8. doi: 10.1136/bmj.2.6049.1415.
Abstract
An investigation into the possible role of endotoxins in the pathogenesis of renal failure in cirrhosis and obstructive jaundice showed the two to be closely related. None of the patients with cirrhosis who had endotoxaemia had other evidence of Gram-negative infection at the time of the study, and the endotoxaemia was therefore probably due to impaired hepatic clearance of toxins normally absorbed from the gastrointestinal tract. In contrast, bacteriological evidence of Gram-negative infection was found in most of the patients with obstructive jaundice and endotoxaemia.
摘要
一项关于内毒素在肝硬化和梗阻性黄疸所致肾衰竭发病机制中可能作用的调查显示，二者密切相关。在研究时，患有内毒素血症的肝硬化患者均无其他革兰氏阴性菌感染的证据，因此内毒素血症可能是由于肝脏对正常从胃肠道吸收的毒素清除功能受损所致。相比之下，大多数患有梗阻性黄疸和内毒素血症的患者存在革兰氏阴性菌感染的细菌学证据。
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