Ruggiero C, Giacomini M, Varnier O E, Gaglio S
Department of Communications, Computer and System Sciences, University of Genova, Italy.
Comput Methods Programs Biomed. 1994 Jun;43(3-4):255-9. doi: 10.1016/0169-2607(94)90077-9.
We present a qualitative model of the interaction between the HIV-1 virus and the human cell, based on qualitative process theory. This model takes into account a previous qualitative model of the cell growth. The model presented here can be regarded as a first step for setting up a comprehensive model of the HIV-1 virus-cell interaction in which the possible points where a drug can attack the virus are evident. The first simulation trials indicate that the presented model reproduces (even though in a simplified way) the features of the real behaviour that have been considered in the modelling phase. Although our simulation is limited in the knowledge it expresses, it still gives a stimulating opportunity for the evaluation of the criteria chosen as discriminant in the interaction between virus and cell.
我们基于定性过程理论，提出了一个关于HIV-1病毒与人体细胞相互作用的定性模型。该模型考虑了先前细胞生长的定性模型。这里提出的模型可被视为建立HIV-1病毒与细胞相互作用综合模型的第一步，在这个综合模型中，药物可能攻击病毒的潜在点是显而易见的。初步模拟试验表明，所提出的模型（尽管是以简化方式）再现了建模阶段所考虑的真实行为特征。虽然我们的模拟在其所表达的知识方面存在局限性，但它仍然为评估在病毒与细胞相互作用中被选为判别标准的准则提供了一个具有启发性的机会。
