Weiss S J, Ward P A
J Immunol. 1982 Jul;129(1):309-13.
Human neutrophils have been studied for their ability to respond with production of O(2) and H2O2 by human neutrophils contain a 1:2 weight ratio of antigen and antibody (molar ratio of 1.5:1). The metabolic stimulation of leukocytes is a linear function of the total amount of complex used. Complexes containing F(ab')2 are ineffective in stimulating leukocytes to produce O(2) and H2O2. The complexes that maximally stimulate production of O(2) by neutrophils differ from those complexes that are 1) most effective in complement fixation, 2) maximally taken up by neutrophils, and 3) most effective in the induction of enzyme release. These findings suggest that immune complex-induced damage in tissues may reflect the effects of a heterogeneous population of immune complexes.
人类中性粒细胞因其产生O₂和H₂O₂的反应能力而受到研究，人类中性粒细胞含有抗原与抗体重量比为1:2（摩尔比为1.5:1）。白细胞的代谢刺激是所用复合物总量的线性函数。含有F(ab')₂的复合物在刺激白细胞产生O₂和H₂O₂方面无效。最大程度刺激中性粒细胞产生O₂的复合物不同于那些：1）在补体固定方面最有效，2）被中性粒细胞最大程度摄取，3）在诱导酶释放方面最有效的复合物。这些发现表明，免疫复合物诱导的组织损伤可能反映了异质性免疫复合物群体的作用。
