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New polyenic antibiotics active against gram-positive and gram-negative bacteria. IV. Structural elucidation of enacyloxin IIa.

作者信息

Watanabe T, Sugiyama T, Takahashi M, Shima J, Yamashita K, Izaki K, Furihata K, Seto H

机构信息

Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.

出版信息

J Antibiot (Tokyo). 1992 Apr;45(4):470-5. doi: 10.7164/antibiotics.45.470.

DOI:10.7164/antibiotics.45.470
PMID:1592680
Abstract

The chemical structure of a unique polyenic antibiotic enacyloxin IIa (former name: fr. 2) produced by Frateuria (formerly Gluconobacter) sp. W-315 has been determined by extensive spectroscopic studies, in particular by NMR spectral analysis. It has a novel non-lactonic structure involving 3,4-dihydroxycyclohexanecarboxylic acid with a chlorine-containing polyenic and polyhydroxy acyl side chain attached as an ester to the 3-hydroxyl substituent of the acid.

摘要

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引用本文的文献

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Int J Mol Sci. 2014 Dec 25;16(1):321-49. doi: 10.3390/ijms16010321.
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Enacyloxin IIa, an inhibitor of protein biosynthesis that acts on elongation factor Tu and the ribosome.恩酰洛新IIa，一种作用于延伸因子Tu和核糖体的蛋白质生物合成抑制剂。
EMBO J. 1996 May 15;15(10):2604-11.