Borradori L, Schmit J C, Stetzkowski M, Dussoix P, Saurat J H, Filthuth I
Dermatology Clinic, Hôpital Cantonal Universitaire.
J Am Acad Dermatol. 1994 Nov;31(5 Pt 2):843-6. doi: 10.1016/s0190-9622(94)70242-x.
Penicillium marneffei infection has emerged as a new potential indicator disease for AIDS in Southeast Asia. We report two additional cases of P. marneffei infection in patients infected with HIV who had traveled to endemic areas and review the mucocutaneous features of previously reported cases. Our two patients had many of the typical features associated with invasive infection: fever, weight loss, anemia, lymphadenopathy, hepatomegaly, pulmonary and gastrointestinal symptoms, as well as skin manifestations such as papular molluscum contagiosum-like lesions and oral lesions. Knowledge of cutaneous signs is important for prompt diagnosis of P. marneffei infection and institution of life-saving therapy with antifungal agents.
马尔尼菲青霉感染已成为东南亚艾滋病一种新的潜在指示性疾病。我们报告另外两例前往流行地区的HIV感染患者发生马尔尼菲青霉感染的病例，并回顾之前报道病例的皮肤黏膜特征。我们的两名患者具有许多与侵袭性感染相关的典型特征：发热、体重减轻、贫血、淋巴结病、肝肿大、肺部和胃肠道症状，以及皮肤表现，如丘疹样传染性软疣样损害和口腔损害。了解皮肤体征对于马尔尼菲青霉感染的及时诊断以及启动抗真菌药物的挽救生命治疗很重要。
