Coryell W, Winokur G, Maser J D, Akiskal H S, Keller M B, Endicott J
University of Iowa College of Medicine, Iowa City.
J Affect Disord. 1994 Jul;31(3):203-10. doi: 10.1016/0165-0327(94)90030-2.
Probands with non-bipolar major depressive disorder (MDD) were grouped according to the consistency across episodes with which depression appeared to arise from situational factors. Situational depression showed significant diagnostic stability across the second and third recurrences in a 10-year follow-up. The relatives of recurrently situational probands had higher neuroticism scores, higher lifetime rates of MDD and, when depressed, fewer endogenous symptoms than did the relatives of non-situational probands. This study joins two others in finding an association between stress-related depression and high familial loadings for MDD. It also illustrates the value of diagnostic consistency across episodes as a means of refining groups for the study of diagnostic subtypes.
患有非双相型重度抑郁症（MDD）的先证者根据抑郁发作时与情境因素相关性的一致性进行分组。在一项为期10年的随访中，情境性抑郁症在第二次和第三次复发时显示出显著的诊断稳定性。复发性情境性先证者的亲属神经质得分更高，MDD的终生患病率更高，且抑郁时的内源性症状比非情境性先证者的亲属少。该研究与其他两项研究一样，发现了与压力相关的抑郁症和MDD的高家族负荷之间的关联。它还说明了跨发作的诊断一致性作为细化诊断亚型研究分组方法的价值。
