自由基、蛋白水解作用与阿尔茨海默病中神经元的退化：β-淀粉样蛋白的联系有多重要？ - Suppr

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超能文献

Free radicals, proteolysis, and the degeneration of neurons in Alzheimer disease: how essential is the beta-amyloid link?

作者信息

Nixon R A, Cataldo A M

机构信息

Laboratories for Molecular Neuroscience, McLean Hospital, Belmont, MA 02178.

出版信息

Neurobiol Aging. 1994 Jul-Aug;15(4):463-9; discussion 473. doi: 10.1016/0197-4580(94)90079-5.

DOI:10.1016/0197-4580(94)90079-5

PMID:7969724

Abstract

摘要

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Free radicals, proteolysis, and the degeneration of neurons in Alzheimer disease: how essential is the beta-amyloid link?自由基、蛋白水解作用与阿尔茨海默病中神经元的退化：β-淀粉样蛋白的联系有多重要？

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Is amyloid causally involved in pathophysiology of Alzheimer's disease?淀粉样蛋白是否在阿尔茨海默病的病理生理学中起因果作用？

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J Neurosci. 2010 Mar 3;30(9):3326-38. doi: 10.1523/JNEUROSCI.5098-09.2010.

In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress.黄原酸三环癸烷-9-基黄原酸酯对β-淀粉样肽（1-42）诱导的氧化应激的体内保护作用。

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Free radicals and disruption of neuronal ion homeostasis in AD: a role for amyloid beta-peptide?

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Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease.由β-淀粉样蛋白（Aβ）和α-突触核蛋白生成过氧化氢和羟基自由基，可能是阿尔茨海默病和帕金森病细胞死亡的一种机制。

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Deciphering an interplay of proteins associated with amyloid β 1-42 peptide and molecular mechanisms of Alzheimer's disease.解析与淀粉样β1-42肽相关的蛋白质之间的相互作用以及阿尔茨海默病的分子机制。

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引用本文的文献

In 2024, the still remains a working hypothesis, no less but certainly no more.在2024年，这仍然只是一个工作假设，仅此而已，绝非定论。

Front Aging Neurosci. 2024 Sep 4;16:1459224. doi: 10.3389/fnagi.2024.1459224. eCollection 2024.

Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism.一氧化氮合酶的诱导和小胶质细胞反应先于由氧化代谢慢性损伤诱导的选择性细胞死亡。

Am J Pathol. 1998 Aug;153(2):599-610. doi: 10.1016/S0002-9440(10)65602-7.

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.散发性阿尔茨海默病中神经元内吞作用增强及蛋白酶向早期内体的传递：β淀粉样蛋白生成增加机制的神经病理学证据

J Neurosci. 1997 Aug 15;17(16):6142-51. doi: 10.1523/JNEUROSCI.17-16-06142.1997.

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