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Free radicals, proteolysis, and the degeneration of neurons in Alzheimer disease: how essential is the beta-amyloid link?

作者信息

Nixon R A, Cataldo A M

机构信息

Laboratories for Molecular Neuroscience, McLean Hospital, Belmont, MA 02178.

出版信息

Neurobiol Aging. 1994 Jul-Aug;15(4):463-9; discussion 473. doi: 10.1016/0197-4580(94)90079-5.

DOI:10.1016/0197-4580(94)90079-5
PMID:7969724
Abstract
摘要

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引用本文的文献

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In 2024, the still remains a working hypothesis, no less but certainly no more.在2024年，这仍然只是一个工作假设，仅此而已，绝非定论。
Front Aging Neurosci. 2024 Sep 4;16:1459224. doi: 10.3389/fnagi.2024.1459224. eCollection 2024.
2
Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism.一氧化氮合酶的诱导和小胶质细胞反应先于由氧化代谢慢性损伤诱导的选择性细胞死亡。
Am J Pathol. 1998 Aug;153(2):599-610. doi: 10.1016/S0002-9440(10)65602-7.
3
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.
散发性阿尔茨海默病中神经元内吞作用增强及蛋白酶向早期内体的传递：β淀粉样蛋白生成增加机制的神经病理学证据
J Neurosci. 1997 Aug 15;17(16):6142-51. doi: 10.1523/JNEUROSCI.17-16-06142.1997.