Ford B, Greene P, Fahn S
Neurological Institute, Columbia-Presbyterian Medical Center, New York, NY.
Neurology. 1994 Nov;44(11):2115-9. doi: 10.1212/wnl.44.11.2115.
We report the development of chronic painful oral or genital sensations in 11 patients with tardive akathisia, tardive dyskinesias, or tardive dystonia. In each case, the pain syndrome became a source of profound distress for the patient, overshadowing all other concurrent neuropsychiatric symptoms, and requiring treatment. Agents effective in treating tardive dyskinesia and tardive akathisia, such as catecholamine depletors, proved effective in reducing the painful sensations. Our observations support the concept of tardive pain as a complication of chronic neuroleptic exposure.
我们报告了11例迟发性静坐不能、迟发性运动障碍或迟发性肌张力障碍患者出现慢性口腔或生殖器疼痛性感觉的情况。在每一例中，疼痛综合征都成为患者极度痛苦的根源，使所有其他并发的神经精神症状黯然失色，并需要进行治疗。事实证明，对治疗迟发性运动障碍和迟发性静坐不能有效的药物，如儿茶酚胺耗竭剂，在减轻疼痛性感觉方面是有效的。我们的观察结果支持迟发性疼痛是慢性抗精神病药物暴露并发症这一概念。
