Martín M J, Marhuenda E, Pérez-Guerrero C, Franco J M
Departamento de Farmacia y Tecnologia Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, España.
Pharmacology. 1994 Sep;49(3):144-50. doi: 10.1159/000139228.
This study was designed to determine the gastroprotective properties of naringin on and the involvement of endogenous prostaglandins in mucosal injury produced by absolute ethanol. Oral pretreatment with the highest dose of naringin (400 mg/kg), 60 min before absolute ethanol was the most effective antiulcer treatment. Subcutaneous administration of indomethacin (10 mg/kg) to the animals treated with naringin (400 mg/kg) partially inhibited gastric protection, but the prostaglandin E2 determination did not show any increase in prostanoid levels. The contents of gastric mucus and total proteins were not significantly modified. Naringin-treated rats showed a marked increase in hexosamine levels, but this increase was less in animals pretreated with indomethacin. These results show that naringin has a 'cytoprotective' effect against ethanol injury in the rat, but this property appears to be mediated by non-prostaglandin-dependent mechanisms.
本研究旨在确定柚皮苷对无水乙醇所致黏膜损伤的胃保护特性以及内源性前列腺素在其中的作用。在给予无水乙醇前60分钟，口服最高剂量的柚皮苷（400毫克/千克）是最有效的抗溃疡治疗方法。对用柚皮苷（400毫克/千克）治疗的动物皮下注射吲哚美辛（10毫克/千克）可部分抑制胃保护作用，但前列腺素E2测定未显示类前列腺素水平有任何升高。胃黏液和总蛋白含量未发生显著改变。用柚皮苷治疗的大鼠己糖胺水平显著升高，但在用吲哚美辛预处理的动物中这种升高幅度较小。这些结果表明，柚皮苷对大鼠乙醇损伤具有“细胞保护”作用，但这种特性似乎是由非前列腺素依赖性机制介导的。
