Baugnet-Mahieu L, Lemaire M, Léonard E D, Léonard A, Gerber G B
CEN/SCK, Laboratory of Radiobiology Radiation Protection Unit, Belgium.
Radiat Res. 1994 Dec;140(3):429-31.
The study aimed to investigate whether the determination of chromosome aberrations in circulating blood lymphocytes could be useful to assess whole-body exposure from radioactive iodine released accidentally. Ten patients treated with two doses of 1850 MBq of 131I given 24 h apart for thyroid cancer were studied for chromosome aberrations (dicentrics) in blood samples taken before and at various times after exposure. The increase in the yield of aberrations caused by the exposure to iodine was small but statistically significant. Compared to published values for whole-body doses after such treatment, this increase appears to be somewhat smaller than expected from dose-effect relationships obtained for an acute exposure of lymphocytes in vitro or in vivo, a fact which could be explained by the low dose rate of the 131I exposure. Thus, in situations where a population was exposed as a result of the release of radioactive iodine, a determination of chromosome aberrations in blood lymphocytes would not appear to be very useful to determine exposure from iodine.
该研究旨在调查测定循环血淋巴细胞中的染色体畸变是否有助于评估因意外释放放射性碘而导致的全身暴露情况。对10例因甲状腺癌接受两剂1850MBq的131I、间隔24小时给药的患者，研究了暴露前及暴露后不同时间采集的血样中的染色体畸变（双着丝粒）情况。碘暴露所致畸变产率的增加虽小，但具有统计学意义。与此类治疗后全身剂量的已发表值相比，这一增加似乎略小于体外或体内淋巴细胞急性暴露的剂量-效应关系所预期的值，这一事实可由131I暴露的低剂量率来解释。因此，在因放射性碘释放而使人群受到暴露的情况下，测定血淋巴细胞中的染色体畸变对于确定碘暴露情况似乎并非非常有用。
