Lipsitz S R, Fitzmaurice G M
Department of Biostatistics, Harvard School of Public Health, Boston MA 02115.
Stat Med. 1994 Jun 30;13(12):1233-9. doi: 10.1002/sim.4780131205.
We consider the sample size required for repeated measures studies when the response variable is binary. We propose the use of weighted least squares (WLS) for calculating the minimum sample size required to detect some minimum clinically important treatment effect. We provide tabulated values of the estimated sample sizes for a simple example and we discuss some practical considerations in determination of sample size with repeated binary responses.
我们考虑当反应变量为二元变量时重复测量研究所需的样本量。我们建议使用加权最小二乘法（WLS）来计算检测到某些最小临床重要治疗效果所需的最小样本量。我们给出了一个简单例子的估计样本量列表值，并讨论了在确定具有重复二元反应的样本量时的一些实际考虑因素。
