Schmidt D, Löffler K U
University Eye Hospital Freiburg, Germany.
Acta Ophthalmol (Copenh). 1994 Jun;72(3):319-25. doi: 10.1111/j.1755-3768.1994.tb02766.x.
The aim of this investigation was to correlate the clinical and histological findings in 85 consecutive patients with temporal arteritis. Particular attention was given to a possible correlation between optic nerve involvement and the presence of giant cells upon histological examination. Severe ischemia as in anterior ischemic optic neuropathy and central retinal arterial occlusion was presented in 37 patients (43%). Giant cells were definitely observed in 32 biopsy specimens (37.6%) and suspected in 11 additional specimens (13%): In 42 specimens (49.3%) no giant cells were present. Our study showed no correlation between the occurrence of severe optic nerve involvement and the histological findings with regard to giant cells. Statistical evaluation also failed to show a significant correlation between the frequency of pain and jaw claudication and the respective histological findings regarding giant cells. In the biopsy specimen of one patient, numerous eosinophilic granulocytes had infiltrated the vessel wall.
本研究旨在关联85例颞动脉炎连续患者的临床与组织学表现。组织学检查时特别关注视神经受累与巨细胞存在之间的可能关联。37例患者（43%）出现了如前部缺血性视神经病变和视网膜中央动脉阻塞那样的严重缺血。在32份活检标本（37.6%）中明确观察到巨细胞，另有11份标本（13%）疑似有巨细胞：42份标本（49.3%）未发现巨细胞。我们的研究表明，严重视神经受累的发生与关于巨细胞的组织学表现之间无关联。统计学评估也未显示疼痛和颌跛行的频率与关于巨细胞的各自组织学表现之间存在显著关联。在1例患者的活检标本中，大量嗜酸性粒细胞浸润了血管壁。
