Fuller C J, Jialal I
Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75235-9052.
Am J Clin Nutr. 1994 Dec;60(6 Suppl):1010S-1013S. doi: 10.1093/ajcn/60.6.1010S.
Evidence continues to accumulate that implicates the oxidative modification of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. Numerous studies have indicated the existence of oxidized LDL in vivo. Supplementation of animals and humans with antioxidants such as alpha-tocopherol have shown promise in reducing the extent of LDL oxidation. However, another possible means of preventing LDL oxidative modification may be by reducing the amount of oxidizable polyunsaturated fatty acids in the LDL particle. Monounsaturated fatty acids have been shown to decrease the susceptibility of LDL oxidation in human studies. It remains to be seen whether saturated fatty acids can do the same. Stearic acid, found in cocoa butter, would be an ideal saturated fatty acid to test because it has a neutral effect on the plasma lipid profile.
越来越多的证据表明，低密度脂蛋白（LDL）的氧化修饰与动脉粥样硬化的发病机制有关。大量研究表明体内存在氧化型LDL。给动物和人类补充抗氧化剂如α-生育酚已显示出有望降低LDL氧化程度。然而，另一种预防LDL氧化修饰的可能方法可能是减少LDL颗粒中可氧化多不饱和脂肪酸的含量。在人体研究中，单不饱和脂肪酸已被证明可降低LDL氧化的易感性。饱和脂肪酸是否也能如此还有待观察。可可脂中发现的硬脂酸将是一种理想的用于测试的饱和脂肪酸，因为它对血浆脂质谱有中性影响。
