Harris W S
Lipid and Arteriosclerosis Prevention Clinic, University of Kansas Medical Center, Kansas City 66103.
Clin Cardiol. 1992 Sep;15(9):636-40. doi: 10.1002/clc.4960150904.
Recent research findings have suggested a role for pharmacologic as well as nutritional antioxidants in the prevention of atherosclerosis. Data from animal studies as well as cell culture experiments have shown that the drug probucol, which has hypocholesterolemic and antioxidant properties, is able to prevent oxidative modification of low density lipoproteins (LDL). Such modification is now believed to play a major part in the initiation and progression of arterial lesions. Nutrients with antioxidant properties such as vitamins C and E, beta-carotene, and mono-unsaturated fatty acids (when they replace polyunsaturated fatty acids) can reduce the susceptibility of LDL to oxidation. Antioxidant therapy, if proven useful, should be considered an adjunct to lipid-lowering therapy in order to have the greatest impact on coronary heart disease.
最近的研究结果表明，药物性和营养性抗氧化剂在预防动脉粥样硬化方面发挥着作用。来自动物研究和细胞培养实验的数据表明，具有降胆固醇和抗氧化特性的药物普罗布考能够预防低密度脂蛋白（LDL）的氧化修饰。现在认为这种修饰在动脉病变的发生和发展中起主要作用。具有抗氧化特性的营养素，如维生素C和E、β-胡萝卜素以及单不饱和脂肪酸（当它们替代多不饱和脂肪酸时），可以降低LDL对氧化的敏感性。如果抗氧化治疗被证明是有效的，那么它应该被视为降脂治疗的辅助手段，以便对冠心病产生最大的影响。
