Roehrs T, Claiborue D, Knox M, Roth T
Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202.
Alcohol Clin Exp Res. 1994 Aug;18(4):831-4. doi: 10.1111/j.1530-0277.1994.tb00047.x.
To test for dose and duration effects of residual sedation, ethanol (0.0, 0.5, and 0.9 g/kg) was administered (at 0830, 1030, and 0730 hr, respectively) to 10 healthy, normal-sleeping men, aged 21-35 years. The Multiple Sleep Latency Test was conducted at 0930, 1130, 1330, 1530, 1730, 1930, and 2130 hr, and a divided attention performance assessment was done at 1400, 1600, 1800, and 2000 hr. Breath ethanol concentration for both doses was 0.04% at 1130 hr, 0.01% at 1330 hr, and 0 at 1530 hr. A significant reduction in sleep latency was observed from 0930 to 1530 hr, but not thereafter. Divided attention performance overall was significantly impaired on the 1400-hr test only. These data again showed residual sedation and suggest residual sedation is time limited and not affected in duration or intensity by dose.
为测试残余镇静的剂量和持续时间效应，分别于08:30、10:30和07:30对10名年龄在21至35岁之间、睡眠正常的健康男性给予乙醇（0.0、0.5和0.9克/千克）。在09:30、11:30、13:30、15:30、17:30、19:30和21:30进行多次睡眠潜伏期测试，并于14:00、16:00、18:00和20:00进行分散注意力表现评估。两种剂量的呼气乙醇浓度在11:30时均为0.04%，13:30时为0.01%，15:30时为0。从09:30至15:30观察到睡眠潜伏期显著缩短，但之后未再出现。仅在14:00的测试中，分散注意力表现总体上受到显著损害。这些数据再次显示了残余镇静作用，并表明残余镇静作用具有时间限制，且在持续时间或强度上不受剂量影响。
