Ozgentaş H E, Pindur A, Spira M, Liu B, Shenaq S
Division of Plastic Surgery, Baylor College of Medicine, Houston, TX 77030.
Ann Plast Surg. 1994 Aug;33(2):171-7. doi: 10.1097/00000637-199408000-00009.
The fate of the Zyderm II, Zyplast, Vicryl, and chromic gut was histologically examined up to 1 year following subcutaneous implantation into rats. Our data demonstrated both Zyderm II and Zyplast to be inert materials without inflammatory response; there was no difference in long-term persistence between these two collagens. Both Vicryl and chromic gut implants caused an intense inflammatory response at 1 month, and Vicryl was completely resorbed before 6 months. The degree of inflammation associated with chromic gut diminished over time, and approximately 67% of the material persisted without reaction up to 1 year.
