Perlmutter A P, Muschter R
Department of Urology, James Buchanan Brady Foundation, New York Hospital-Cornell Medical Center, New York, New York.
Urology. 1994 Dec;44(6):847-55. doi: 10.1016/s0090-4295(94)80169-x.
To study laser-tissue interaction and develop unifying principles for the optimization of free beam side fire neodymium:yttrium-aluminum-garnet (Nd:YAG) laser coagulation prostatectomy.
The heating patterns and coagulation volumes created by different right angle deflecting fibers were studied at different wattages and times in potato and canine models.
In the potato, higher wattage resulted in deeper and more rapid heating. The high power density fibers created lesions of smaller volume which increased less with rising wattage than those fibers of lower power density. In the canine model, carbonization decreased heat penetration, and "popcorn" decreased superficial temperature without altering lesion size as long as it occurred without carbonization. As lasing progressed, smaller incremental increases in coagulation depth were achieved.
To optimize coagulation laser prostatectomy, the surgeon should operate at the highest wattage which does not cause carbonization. The visualized intraoperative laser-tissue interaction allows the adjustment of laser power during the case as needed.
研究激光与组织的相互作用，并制定统一原则以优化自由光束侧射钕：钇铝石榴石（Nd:YAG）激光凝固前列腺切除术。
在土豆和犬类模型中，研究不同直角偏转光纤在不同功率和时间下产生的加热模式和凝固体积。
在土豆中，较高功率导致更深、更快的加热。高功率密度光纤产生的损伤体积较小，与低功率密度光纤相比，随着功率增加其体积增加较少。在犬类模型中，碳化会降低热穿透，而“爆米花”现象在不发生碳化的情况下会降低表面温度且不改变损伤大小。随着激光照射的进行，凝固深度的增量增加较小。
为优化凝固性激光前列腺切除术，外科医生应在不引起碳化的最高功率下操作。术中可视化的激光与组织的相互作用允许根据需要在手术过程中调整激光功率。
