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黑色素化新生隐球菌对紫外线的敏感性降低。

Decreased susceptibility of melanized Cryptococcus neoformans to UV light.

作者信息

Wang Y, Casadevall A

机构信息

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.

出版信息

Appl Environ Microbiol. 1994 Oct;60(10):3864-6. doi: 10.1128/aem.60.10.3864-3866.1994.

DOI:10.1128/aem.60.10.3864-3866.1994
PMID:7986054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC201897/
Abstract

Melanized Cryptococcus neoformans cells were less susceptible than nonmelanized cells to the fungicidal effects of UV light. Phenoloxidase-catalyzed production of melanin-like pigments may serve to protect the fungus against ionizing radiation.

摘要

黑色素化的新型隐球菌细胞比未黑色素化的细胞对紫外线的杀菌作用更不敏感。酚氧化酶催化产生的类黑色素色素可能有助于保护真菌免受电离辐射。

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本文引用的文献

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Saprophytic sources of Cryptococcus neoformans associated with the pigeon (Columba livia).与鸽子（家鸽）相关的新生隐球菌腐生来源。
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Purification and characterization of a phenoloxidase (laccase) from the lignin-degrading basidiomycete PM1 (CECT 2971).从木质素降解担子菌PM1（CECT 2971）中纯化和鉴定一种酚氧化酶（漆酶）
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3
Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase.新型隐球菌双酚氧化酶的生化与分子特性：鉴定为漆酶
J Bacteriol. 1994 Feb;176(3):656-64. doi: 10.1128/jb.176.3.656-664.1994.
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Melanin reduces ultraviolet-induced DNA damage formation and killing rate in cultured human melanoma cells.黑色素可减少紫外线诱导的培养人黑色素瘤细胞中的DNA损伤形成及杀伤率。
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Antioxidant function of fungal melanin.真菌黑色素的抗氧化功能。
J Bacteriol. 1993 Nov;175(21):7102-4. doi: 10.1128/jb.175.21.7102-7104.1993.
6
Phenoloxidase activity and virulence in isogenic strains of Cryptococcus neoformans.新型隐球菌同基因菌株中的酚氧化酶活性与毒力
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Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment.获得性免疫缺陷综合征患者的隐球菌病。诊断特征与治疗结果。
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