Gerber M A, Zalneraitis E L
Department of Pediatrics, University of Connecticut Health Center, Farmington 06030-1515.
Pediatr Neurol. 1994 Jul;11(1):41-3. doi: 10.1016/0887-8994(94)90088-4.
To determine the prevalence of clinically significant nervous system disease attributable to transplacental transmission of Borrelia burgdorferi, we surveyed neurologists in areas of the United States in which Lyme disease is endemic (i.e., Massachusetts, Rhode Island, Connecticut, New York, New Jersey, Wisconsin, and Minnesota). Overall, 162 of the 176 (92%) pediatric neurologists contacted responded to the survey with a range of 90-100% in the different geographic areas. One pediatric neurologist was following 3 children who were labeled as having "congenital Lyme disease," but none of the 3 met our case definition. None of the other pediatric neurologists surveyed had ever seen a child whose mother had been diagnosed as having Lyme disease during pregnancy. Similarly, none of the 37 adult neurologists in Connecticut surveyed had ever seen a child whose mother had been diagnosed as having had Lyme disease during pregnancy. We conclude that congenital neuroborreliosis is either not occurring or is occurring at an extremely low rate in areas endemic for Lyme disease.
为了确定由伯氏疏螺旋体经胎盘传播所致的具有临床意义的神经系统疾病的患病率，我们对美国莱姆病流行地区（即马萨诸塞州、罗德岛州、康涅狄格州、纽约州、新泽西州、威斯康星州和明尼苏达州）的神经科医生进行了调查。总体而言，176名受访儿科神经科医生中有162名（92%）回复了调查，不同地理区域的回复率在90%至100%之间。有一位儿科神经科医生正在追踪3名被诊断为患有“先天性莱姆病”的儿童，但这3名儿童均不符合我们的病例定义。其他接受调查的儿科神经科医生中，没有一人见过其母亲在孕期被诊断为患有莱姆病的儿童。同样，在康涅狄格州接受调查的37名成人神经科医生中，也没有一人见过其母亲在孕期被诊断为患有莱姆病的儿童。我们得出结论，在莱姆病流行地区，先天性神经型疏螺旋体病要么没有发生，要么发生率极低。
