Saakian M R, Kondrashova M N, Vysochina I V
Izv Akad Nauk Ser Biol. 1994 Jul-Aug(4):596-604.
Succinic acid is involved in correction of energy metabolism as a powerful source of protons and ATP and as an antioxidant. Some food products contain succinic acid, specifically those, whose preparation involves anaerobic processes, and some berries. However many everyday food products are devoid of succinic acid. The lack of succinic acid in food can be compensated by its use as a food additive. It has been shown that consumption of succinic acid by rats results in a decreased weight increment of adult animals kept on abundant sugar diet. Both therapeutical (higher) and nutritive (lower) doses of succinic acid decrease metabolic acidosis and restore the transaminase activity in patients. The both metabolic parameters indicate correction of energy metabolism.
琥珀酸作为质子和ATP的强大来源以及一种抗氧化剂，参与能量代谢的调节。一些食品含有琥珀酸，特别是那些制备过程涉及厌氧过程的食品以及一些浆果。然而，许多日常食品不含琥珀酸。食品中琥珀酸的缺乏可以通过将其用作食品添加剂来弥补。研究表明，给大鼠喂食琥珀酸会导致食用高糖饮食的成年动物体重增加减少。治疗剂量（较高）和营养剂量（较低）的琥珀酸均可降低患者的代谢性酸中毒并恢复转氨酶活性。这两个代谢参数均表明能量代谢得到了调节。
