Rasgon N, Ananth J, Mena I, Krout B, Boone K
Harbor-UCLA Medical Center, Torrance.
Can J Psychiatry. 1994 Sep;39(7):429-32. doi: 10.1177/070674379403900707.
This paper describes a previously sufficiently functioning 57 year old man who presented with a recent onset of frontal behaviour. Partial agenesis of corpus callosum was an incidental finding on a computerized tomography scan. The EEG was within normal limits and neuropsychological testing did not reveal any interhemispheric disconnection. A SPECT-Scan revealed bilateral hypoperfusion, consistent with Alzheimer's dementia. Normal functioning up to 50 years of age and a later manifestation of Alzheimer's disease along with agenesis of carpus callosum is of clinical interest as such an association has not been published.
本文描述了一名57岁此前功能充分正常的男性，其近期出现额叶行为。胼胝体部分发育不全是计算机断层扫描的偶然发现。脑电图正常，神经心理学测试未发现任何半球间分离。单光子发射计算机断层扫描显示双侧灌注不足，符合阿尔茨海默病。50岁前功能正常，随后出现阿尔茨海默病以及胼胝体发育不全，这种关联尚未见报道，因此具有临床研究价值。
