Wu C L, Sloan P, Read A P, Harris R, Thakker N
Department of Medical Genetics, University of Manchester, St. Mary's Hospital, Manchester, United Kingdom.
Cancer Res. 1994 Dec 15;54(24):6484-8.
Loss of heterozygosity indicative of the presence of tumor suppressor genes on chromosome 3p is commonly observed in carcinomas of various tissues. We have examined loss of heterozygosity on chromosome 3p in 27 oral squamous cell carcinomas using 15 highly informative microsatellite polymorphisms and constructed a deletion map of chromosome 3p. Overall, loss of heterozygosity at one or more loci was observed in 14 tumors (approximately 52%). A majority of these tumors (86%) show loss in more than one area. Three distinct regions were identified: 3p13-3p21.1, 3p21.3-3p23, and 3p25. These data suggest a role for at least three tumor suppressor genes on chromosome 3p in oral squamous carcinomas. The regions of deletions overlap with those described for carcinomas of other tissues and parallel those observed in lung carcinomas. This may reflect the common etiology of the two cancers.
在各种组织的癌中普遍观察到3号染色体短臂上存在肿瘤抑制基因的杂合性缺失。我们使用15个高度信息丰富的微卫星多态性检测了27例口腔鳞状细胞癌中3号染色体短臂的杂合性缺失，并构建了3号染色体短臂的缺失图谱。总体而言，在14个肿瘤中观察到一个或多个位点的杂合性缺失（约52%）。这些肿瘤中的大多数（86%）在多个区域出现缺失。确定了三个不同的区域：3p13 - 3p21.1、3p21.3 - 3p23和3p25。这些数据表明3号染色体短臂上至少有三个肿瘤抑制基因在口腔鳞状癌中起作用。缺失区域与其他组织癌中描述的区域重叠，并且与肺癌中观察到的区域相似。这可能反映了这两种癌症的共同病因。
