Briner W W, Kayrouz G A, Chanak M X
Compendium. 1994 Sep;15(9):1158, 1160, 1162 passim; quiz 1170.
Antimicrobial mouthrinses can play an important role in maintaining oral health by killing cariogenic organisms and preventing plaque and gingivitis. The active ingredients are adsorbed by oral tissues and then gradually released into the saliva. In this article, the effectiveness of a substantive chlorhexidine and a nonsubstantive phenolic antimicrobial mouthrinse were tested. When compared, the results indicated that the two types of mouthrinses are equally effective at killing salivary microbes for up to 30 minutes after rinsing. The prescriptive substantive rinse, however, continued its microbicidal effect for a longer duration (up to 5 hours) than the over-the-counter nonsubstantive rinse. The substantive rinse showed pronounced and measurable zones of inhibition around each well in the agar diffusion assay where the nonsubstantive rinse showed no zone around any well at any time. The substantive rinse also showed a superior ability to inhibit the growth of 28 oral microbes, including some putative periodontopathogens, which were assayed.
抗菌漱口水通过杀灭致龋微生物、预防牙菌斑和牙龈炎，在维持口腔健康方面发挥着重要作用。其活性成分会被口腔组织吸附，然后逐渐释放到唾液中。在本文中，对一种长效洗必泰和一种非长效酚类抗菌漱口水的效果进行了测试。对比结果表明，两种漱口水在漱口后长达30分钟内对杀灭唾液微生物的效果相同。然而，处方用长效漱口水的杀菌效果持续时间更长（长达5小时），超过了非处方非长效漱口水。在琼脂扩散试验中，长效漱口水在每个孔周围显示出明显且可测量的抑菌圈，而非长效漱口水在任何时候任何孔周围均未显示出抑菌圈。长效漱口水还表现出更强的抑制28种口腔微生物生长的能力，其中包括一些经检测的假定牙周病原体。
