肠球菌属对厄他培南类抗生素的敏感性差异
Differential susceptibilities of enterococcal species to elfamycin antibiotics.
作者信息
Miele A, Goldstein B P, Bandera M, Jarvis C, Resconi A, Williams R J
机构信息
Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano, Varese, Italy.
出版信息
J Clin Microbiol. 1994 Aug;32(8):2016-8. doi: 10.1128/jcm.32.8.2016-2018.1994.
Abstract
The elfamycins are a class of naturally occurring antibiotics not currently used in the therapy of human disease. Enterococcus faecium and closely related species (Enterococcus durans and Enterococcus hirae) are susceptible to these antibiotics, while isolates of Enterococcus faecalis and other enterococcal species are highly resistant. Among enterococci, susceptibility or resistance to elfamycins appears to be determined by the bacterial protein synthesis elongation factor EF-Tu. Elfamycin susceptibility may be a useful adjunct for rapidly distinguishing E. faecalis and E. faecium in the clinical microbiology laboratory and/or as a supplementary test for use in determining the species of enterococci.
摘要
埃弗霉素是一类目前未用于人类疾病治疗的天然抗生素。粪肠球菌及密切相关菌种（耐久肠球菌和希拉肠球菌）对这些抗生素敏感，而粪肠球菌及其他肠球菌属的分离株则具有高度抗性。在肠球菌中，对埃弗霉素的敏感性或抗性似乎由细菌蛋白质合成延伸因子EF-Tu决定。埃弗霉素敏感性可能是临床微生物实验室快速区分粪肠球菌和屎肠球菌的有用辅助手段，和/或作为确定肠球菌种类的补充试验。
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