来自马丁苋的5,6,7-三取代黄酮的抗肿瘤和细胞毒性筛选
Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana.
作者信息
Pomilio A B, Solá G A, Mayer A M, Rumi L S
机构信息
PROPLAME-CONICET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
出版信息
J Ethnopharmacol. 1994 Aug;44(1):25-33. doi: 10.1016/0378-8741(94)90095-7.
An in vivo antitumor screening of extracts of Gomphrena martiana indicated positive activity in the petroleum ether extract, and its further bioactivity-directed fractionation resulted in a lipophilic flavonoid fraction. Upon inoculation of various doses of 5,6,7-trisubstituted flavones on two murine tumor lines, Sarcoma 180 and Ehrlich's carcinoma, a decrease of tumor growth was observed. An in vitro KB cultured cell screen indicated cytotoxicity.
对紫茉莉提取物进行的体内抗肿瘤筛选表明，石油醚提取物具有阳性活性，对其进一步进行生物活性导向分离得到了一个亲脂性黄酮类组分。在两种小鼠肿瘤模型肉瘤180和艾氏癌中接种不同剂量的5,6,7-三取代黄酮后，观察到肿瘤生长减缓。体外KB培养细胞筛选显示出细胞毒性。
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