Boschman C R, Stryker S, Reddy J K, Rao M S
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611.
Am J Pathol. 1994 Dec;145(6):1291-5.
To evaluate the incidence and stage at which p53 alterations occur in human pancreatic carcinogenesis, we examined primary and metastatic carcinomas, carcinoma in situ, and hyperplastic lesions with and without atypia for p53 protein overexpression by immunohistochemical procedure. Overexpression of p53 was observed in 40% (10/25) of primary tumors, 29% (2/7) of metastatic tumors, 36% (5/14) of carcinoma in situ, and 35% (6/17) of hyperplastic lesions. These results suggest that p53 protein overexpression is not only a common genetic alteration but also occurs very early in the development of these tumors. It is suggested that p53 overexpression can be used as a marker to identify precursor lesions that have increased potential to develop into malignant tumors.
为评估p53改变在人类胰腺癌发生过程中的发生率及出现阶段，我们通过免疫组化方法检测了原发性癌和转移性癌、原位癌以及伴有或不伴有异型增生的增生性病变中p53蛋白的过表达情况。在25例原发性肿瘤中有40%（10/25）观察到p53过表达，7例转移性肿瘤中有29%（2/7），14例原位癌中有36%（5/14），17例增生性病变中有35%（6/17）。这些结果表明，p53蛋白过表达不仅是一种常见的基因改变，而且在这些肿瘤的发生过程中很早就出现了。提示p53过表达可作为一种标志物，用于识别具有发展为恶性肿瘤更高潜力的前驱病变。
