Izatt J A, Hee M R, Swanson E A, Lin C P, Huang D, Schuman J S, Puliafito C A, Fujimoto J G
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge.
Arch Ophthalmol. 1994 Dec;112(12):1584-9. doi: 10.1001/archopht.1994.01090240090031.
To demonstrate a new diagnostic technique, optical coherence tomography, for high-resolution cross-sectional imaging of structures in the anterior segment of the human eye in vivo. Optical coherence tomography is a new, noninvasive, noncontact optical imaging modality that has spatial resolution superior to that of conventional clinical ultrasonography (< 20 microns) and high sensitivity (dynamic range, > 90 dB).
Survey of intraocular structure and dimension measurements.
Laboratory.
Convenience sample.
Correlation with range of accepted normal intraocular structure profiles and dimensions.
Direct in vivo measurements with micrometer-scale resolution were performed of corneal thickness and surface profile (including visualization of the corneal epithelium), anterior chamber depth and angle, and iris thickness and surface profile. Dense nuclear cataracts were successfully imaged through their full thickness in a cold cataract model in calf eyes in vitro.
Optical coherence tomography has potential as a diagnostic tool for applications in noncontact biometry, anterior chamber angle assessment, identification and monitoring of intraocular masses and tumors, and elucidation of abnormalities of the cornea, iris, and crystalline lens.
展示一种新的诊断技术——光学相干断层扫描，用于在体对人眼前节结构进行高分辨率横断面成像。光学相干断层扫描是一种新的非侵入性、非接触式光学成像方式，其空间分辨率优于传统临床超声检查（<20微米），且灵敏度高（动态范围>90分贝）。
对眼内结构和尺寸测量进行研究。
实验室。
便利样本。
与公认的正常眼内结构轮廓和尺寸范围的相关性。
对角膜厚度和表面轮廓（包括角膜上皮可视化）、前房深度和角度以及虹膜厚度和表面轮廓进行了具有微米级分辨率的直接在体测量。在体外小牛眼冷白内障模型中成功对致密核性白内障进行了全层成像。
光学相干断层扫描有潜力作为一种诊断工具，应用于非接触生物测量、前房角评估、眼内肿物和肿瘤的识别与监测，以及阐明角膜、虹膜和晶状体的异常情况。
