Brown S A, Haberman C, Finco D R
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
Am J Vet Res. 1996 Dec;57(12):1702-5.
To evaluate utility of a method for estimating glomerular filtration rate after a single i.v. injection of inulin.
Cats that were renal intact (n = 3) or had renal mass reduced by partial nephrectomy (n = 6).
Plasma clearance of inulin (PCln) was taken as the quotient of the administered dose of inulin (150 mg) divided by the area under the plasma inulin concentration versus time curve determined by 3 methods (PCln1-PCln3). Results for PCln were compared with simultaneously obtained values for urinary clearance of exogenous creatinine (CCr), an accepted method for the estimation of glomerular filtration rate (GFR) in cats.
Values for PCln were closely related (R2 ranged from 0.951 to 0.972, P < 0.0001 in all instances) to CCr. However, PCln3 provided an estimate of GFR that consistently overestimated CCr.
Determination of PCln by use of PCln1 and PCln2 provided a reliable estimate of GFR in cats of this study.
Determination of PCln appears to provide a reliable estimate of GFR in cats with early-stage renal disease and no evidence of derangement of body fluid status. In particular, PCln2, which requires only 3 determinations of plasma inulin concentration, should be considered when an estimate of GFR is sought in a cat with suspected early-stage renal disease.
评估单次静脉注射菊粉后估算肾小球滤过率方法的实用性。
肾脏完整的猫（n = 3）或经部分肾切除使肾质量减少的猫（n = 6）。
菊粉的血浆清除率（PCln）通过菊粉给药剂量（150毫克）除以用3种方法（PCln1 - PCln3）测定的血浆菊粉浓度 - 时间曲线下的面积来计算。将PCln的结果与同时获得的外源性肌酐尿清除率（CCr）的值进行比较，CCr是估算猫肾小球滤过率（GFR）的公认方法。
PCln的值与CCr密切相关（R²范围为0.951至0.972，在所有情况下P < 0.0001）。然而，PCln3对GFR的估算始终高估了CCr。
使用PCln1和PCln2测定PCln可为本研究中的猫提供可靠的GFR估算值。
测定PCln似乎可为患有早期肾病且无体液状态紊乱证据的猫提供可靠的GFR估算值。特别是，PCln2仅需要测定3次血浆菊粉浓度，在寻求估算疑似患有早期肾病猫的GFR时应予以考虑。
