Kiuttu J, Hartikainen A L, Mäkitalo R, Ruuska P
Department of Medical Microbiology, University of Oulu, Finland.
Gynecol Obstet Invest. 1994;37(3):160-3. doi: 10.1159/000292548.
The significance of antinuclear antibodies (ANA) was studied in 51 ANA-positive women who had had a total of 170 pregnancies. 60 ANA-negative age- and parity-matched women with a total of 142 pregnancies served as controls. The perinatal mortality rate in the ANA-positive group was 18.6% (8/43), while there were no perinatal deaths in the ANA-negative control group. All the perinatal losses were stillbirths. The rate of spontaneous abortions was low in both groups, 2.0 vs. 3.3%, respectively. The ANA titer, complement-fixing activity and antigenic specificity did not correlate with the outcome of the pregnancy. Two infants of the ANA-positive women (3.9%) had a congenital atrioventricular heart block. In both cases the ANA was of the complement-fixing type.
对51名抗核抗体（ANA）阳性且共有170次妊娠的女性进行了抗核抗体意义的研究。选取60名年龄和产次匹配、ANA阴性且共有142次妊娠的女性作为对照。ANA阳性组的围产期死亡率为18.6%（8/43），而ANA阴性对照组无围产期死亡病例。所有围产期死亡均为死产。两组自然流产率均较低，分别为2.0%和3.3%。ANA滴度、补体结合活性和抗原特异性与妊娠结局无关。ANA阳性女性中有两名婴儿（3.9%）患有先天性房室传导阻滞。两例中ANA均为补体结合型。
