Tomera J F, Lilford K, Harakal C
Department of Anaesthesiology, Harvard Medical School, Boston, MA 02114, USA.
Food Chem Toxicol. 1995 Jun;33(6):529-35. doi: 10.1016/0278-6915(95)00014-s.
Heart disease remains a major public health issue. In this study we aimed to achieve a greater mathematical and mechanistic understanding of the relationship between exposure to heavy metals and heart disease. Measurements of calcium and cadmium levels were made by flame atomic absorption spectrophotometry in tissue from hypertensive and non-hypertensive rabbits. Relationships between hypertrophy, calcium and cadmium were tested using multiple regression analysis. Multiple linear relationships occurred that showed the dependence of hypertrophy on calcium and cadmium levels, and of calcium accumulation on cadmium and hypertrophy. These data provide an insight into the mechanisms of heavy metal accumulation and the development of cardiovascular hypertrophy.
心脏病仍然是一个主要的公共卫生问题。在本研究中，我们旨在对接触重金属与心脏病之间的关系有更深入的数学和机制理解。通过火焰原子吸收分光光度法测量了高血压和非高血压兔子组织中的钙和镉水平。使用多元回归分析测试了肥大、钙和镉之间的关系。出现了多重线性关系，表明肥大对钙和镉水平的依赖性，以及钙积累对镉和肥大的依赖性。这些数据为重金属积累机制和心血管肥大的发展提供了见解。
