Tomera J F, Harakal C
Clinical Pharmacology Laboratory of the Anesthesia Services of Shriners Burns Institute, Boston, MA, USA.
Food Chem Toxicol. 1997 Jul;35(7):713-8. doi: 10.1016/s0278-6915(97)00042-2.
High blood pressure causes heart disease and remains a major public health issue. This paper expands mathematically and mechanically on environmental heavy metal exposure and heart disease. In rabbits, mean blood pressure was measured by direct puncture of the middle ear artery. Measurements of calcium and cadmium levels were made by flame atomic absorption spectrophotometry in tissue from hypertensive and non-hypertensive rabbits. Relationships between blood pressure, hypertrophy, calcium and cadmium were tested using multiple regression analysis. Multiple linear relationships occurred showing the dependence of high blood pressure on hypertrophy, calcium and cadmium: hypertrophy on calcium, cadmium and high blood pressure; and calcium on cadmium, high blood pressure and hypertrophy. These data provide insight into the mechanism of elevated blood pressure on heavy metal and calcium accumulation, and cardiac hypertrophy.
高血压会引发心脏病，并且仍然是一个主要的公共卫生问题。本文在数学和力学方面对环境重金属暴露与心脏病之间的关系进行了拓展。在兔子身上，通过直接穿刺中耳动脉来测量平均血压。采用火焰原子吸收分光光度法对高血压和非高血压兔子组织中的钙和镉水平进行测量。使用多元回归分析来检验血压、心肌肥厚、钙和镉之间的关系。结果呈现出多种线性关系，表明高血压依赖于心肌肥厚、钙和镉；心肌肥厚依赖于钙、镉和高血压；钙依赖于镉、高血压和心肌肥厚。这些数据为深入了解血压升高对重金属和钙积累以及心肌肥厚的作用机制提供了依据。
