Tomera J F, Lilford K, Friend K D, Kukulka S P, Harakal C
Department of Anaesthesiology, Harvard Medical School, Boston, MA 02114, USA.
Food Chem Toxicol. 1995 Jul;33(7):579-90. doi: 10.1016/0278-6915(95)00028-z.
At present, the significance of calcium accumulation in the aetiology of coronary artery disease (CAD) in humans is not known, except only to exacerbate the condition. In an attempt to understand ionic disturbances in vasculature derived from cardiovascular abnormalities, soft tissues from hypertensive models were examined. The study hypothesis was to see if basic cardiovascular regulatory sites in hypertensive models accumulated greater amounts of Ca2+. Calcium levels were measured by flame atomic absorption spectrophotometry in tissue derived from two types of hypertensive rabbits. Both models of hypertension developed mean arterial pressures of at least 50 mm Hg greater than those of controls over a 5-wk period. Significant increases in calcium levels were found in left ventricle and aorta derived from both hypertensive groups compared with controls. Renal cortex and medulla were not significantly different among any of the groups. These levels corroborate the findings of others which show increased calcium levels in cardiovascular tissues in experimental hypertension in rabbits. Although there have been several studies that have shown the relationship between calcium, hypertension and CAD, this is the first study to look at calcium accumulation rather that the effects of calcium channel blockers. The link between hypertension and calcium accumulation in a number of tissues may be important in the development of CAD and other cardiac dysfunction.
目前，除了会使病情加重外，钙在人类冠状动脉疾病（CAD）病因中的作用尚不清楚。为了了解心血管异常引起的血管系统离子紊乱，对高血压模型的软组织进行了检查。该研究的假设是观察高血压模型中的基本心血管调节部位是否积累了更多的Ca2+。通过火焰原子吸收分光光度法测量了两种高血压兔组织中的钙水平。在5周的时间里，两种高血压模型的平均动脉压都比对照组至少高50毫米汞柱。与对照组相比，两个高血压组的左心室和主动脉中的钙水平均显著升高。肾皮质和髓质在任何组之间均无显著差异。这些水平证实了其他研究结果，即在实验性高血压兔的心血管组织中钙水平升高。尽管有几项研究表明了钙、高血压和CAD之间的关系，但这是第一项研究钙积累而非钙通道阻滞剂作用的研究。高血压与许多组织中钙积累之间的联系可能在CAD和其他心脏功能障碍的发展中起重要作用。
