[莱姆病的神经系统表现。附22例报告]

[Neurologic manifestations in Lyme disease. Apropos of 22 cases].

作者信息

Ragnaud J M, Morlat P, Ferrer X, Orgogozo J M, Julien J, Beylot J, Aubertin J

机构信息

Clinique médicale et des maladies infectieuses, hôpital Pellegrin, Bordeaux.

出版信息

Rev Med Interne. 1993;14(10):985. doi: 10.1016/s0248-8663(05)80103-1.

DOI:10.1016/s0248-8663(05)80103-1

PMID:8009078

Abstract

The main clinical and biological features of 22 cases of neurological forms of Lyme disease are reviewed. Radiculitis (n = 15), cranial nevritis (n = 7), meningitis (n = 5) and encephalitis (n = 4) are often associated. Tick bites were previously noticed in only 40% of cases; erythema chronicum migrans in 73%, "one to six months before the onset of neurological symptoms". Titers of Borrelia Burgdorferi antibodies were always above 1/256. Among 18 patients, DR W2 HLA haplotype was present in 15.

摘要

回顾了22例莱姆病神经型的主要临床和生物学特征。神经根炎（n = 15）、颅神经炎（n = 7）、脑膜炎（n = 5）和脑炎（n = 4）常合并出现。仅40%的病例之前有蜱叮咬史；73%的病例有慢性游走性红斑，“在神经症状出现前1至6个月”出现。伯氏疏螺旋体抗体滴度始终高于1/256。18例患者中，15例存在DRW2 HLA单倍型。