Schaffer F M, Newton J A
Department of Pediatrics, State University of New York at Buffalo 14222.
J Perinatol. 1994 Mar-Apr;14(2):114-7.
Women with common variable immunodeficiency have decreased serum concentrations of all immunoglobulin isotypes. Their offspring are at a high risk for the development of neonatal infection caused by the minimal quantity of maternal immunoglobulin G (IgG) transplacentally transported during pregnancy. These patients are usually given frequent doses of exogenous IgG during the third trimester to increase the amount of IgG transported to the fetus. In this article, we describe the results of initiating a therapeutic regimen of high doses (400 mg/kg) of intravenous gamma globulin every 3 weeks starting in the first trimester of pregnancy for a woman with common variable immunodeficiency. In contrast to most reports, this regimen enables the patient to attain high serum IgG levels early in pregnancy, thereby decreasing the possibility of perinatal sepsis. In addition, the need for frequent administration of intravenous gamma globulin during the third trimester is bypassed with the attainment of protective IgG concentrations in the newborn infant.
普通可变免疫缺陷女性的所有免疫球蛋白同种型血清浓度均降低。她们的后代因孕期经胎盘转运的母体免疫球蛋白G（IgG）量极少而面临新生儿感染的高风险。这些患者通常在孕晚期频繁给予外源性IgG，以增加转运至胎儿的IgG量。在本文中，我们描述了一名普通可变免疫缺陷女性从妊娠早期开始每3周接受一次高剂量（400mg/kg）静脉注射丙种球蛋白治疗方案的结果。与大多数报告不同的是，该方案使患者在妊娠早期就能达到高血清IgG水平，从而降低围产期败血症的可能性。此外，由于新生儿达到了保护性IgG浓度，从而避免了在孕晚期频繁给予静脉注射丙种球蛋白的需要。
