Larnicol N, Wallois F, Berquin P, Gros F, Rose D
Laboratoire de Neurophysiologie, CNRS-URA 1331, Université de Picardie, Amiens, France.
J Physiol Paris. 1994;88(1):81-8. doi: 10.1016/0928-4257(94)90094-9.
The overall pattern of c-fos immunoreactivity was studied in the brainstem and spinal cord of cats subjected to moderate hypoxia or hypercapnia. In control cats (normoxic, normocapnic), c-fos was expressed mainly in pontine and periaqueductal grey but not in brainstem structures engaged in respiratory control nor in the spinal cord. Both hypoxia and hypercapnia induced c-fos expression in the parabrachial area (pneumotaxic center). In the retrotrapezoid nucleus, a structure involved in respiratory rhythmogenesis and chemoreception, immunoreactivity was detected in hypoxic but not in hypercapnic cats. Neurons in the nucleus raphe pallidus preferentially expressed c-fos in response to hypercapnia. Labelled neurons were concentrated in the dorsal and gelatinosus subnuclei of the solitary tract following hypoxia and hypercapnia, respectively. Our data suggest that some neurons that express c-fos in hypoxic or hypercapnic cats may be involved in coordination of cardiovascular and respiratory function.
在经历中度缺氧或高碳酸血症的猫的脑干和脊髓中研究了c-fos免疫反应性的总体模式。在对照猫（常氧、常碳酸血症）中，c-fos主要在脑桥和导水管周围灰质中表达，但不在参与呼吸控制的脑干结构或脊髓中表达。缺氧和高碳酸血症均诱导臂旁区域（呼吸调整中枢）的c-fos表达。在参与呼吸节律产生和化学感受的后梯形核中，在缺氧的猫中检测到免疫反应性，而在高碳酸血症的猫中未检测到。中缝苍白核中的神经元对高碳酸血症优先表达c-fos。分别在缺氧和高碳酸血症后，标记的神经元集中在孤束的背侧和胶状亚核中。我们的数据表明，在缺氧或高碳酸血症的猫中表达c-fos的一些神经元可能参与心血管和呼吸功能的协调。
