Projan S J, Brown-Skrobot S, Schlievert P M, Vandenesch F, Novick R P
Applied Microbiology, Inc., New York, New York.
J Bacteriol. 1994 Jul;176(14):4204-9. doi: 10.1128/jb.176.14.4204-4209.1994.
Glycerol monolaurate (GML) is a naturally occurring surfactant that is used widely as an emulsifier in the food and cosmetics industries and is generally regarded as lacking in important biological activities. The recent observation that it inhibits the production of staphylococcal toxic shock toxin-1 (P. M. Schlievert, J. R. Deringer, M. H. Kim, S. J. Projan, and R. P. Novick, Antimicrob. Agents Chemother. 36:626-631, 1992) is therefore rather surprising and raises the interesting question of how such a compound might interact with cells. In this report, we show that GML inhibits the synthesis of most staphylococcal toxins and other exoproteins and that it does so at the level of transcription. We find that GML blocks the induction but not the constitutive synthesis of beta-lactamase, suggesting that it acts by interfering with signal transduction.
月桂酸单甘油酯（GML）是一种天然存在的表面活性剂，在食品和化妆品行业中广泛用作乳化剂，通常被认为缺乏重要的生物活性。因此，最近观察到它能抑制葡萄球菌中毒性休克毒素-1的产生（P.M.施利弗特、J.R.德林格、M.H.金、S.J.普罗扬和R.P.诺维克，《抗菌药物与化疗》，第36卷，第626 - 631页，1992年）相当令人惊讶，并引发了一个有趣的问题，即这样一种化合物可能如何与细胞相互作用。在本报告中，我们表明GML抑制大多数葡萄球菌毒素和其他外蛋白的合成，并且是在转录水平上实现的。我们发现GML阻断β-内酰胺酶的诱导合成但不影响其组成型合成，这表明它通过干扰信号转导起作用。
