金黄色葡萄球菌伍德46株α毒素基因的一级序列。
Primary sequence of the alpha-toxin gene from Staphylococcus aureus wood 46.
作者信息
Gray G S, Kehoe M
出版信息
Infect Immun. 1984 Nov;46(2):615-8. doi: 10.1128/iai.46.2.615-618.1984.
Abstract
The complete DNA sequence of a cloned alpha-toxin gene from Staphylococcus aureus was determined. The amino acid sequence of the alpha-toxin protein, predicted from the DNA sequence, was described and compared with published data. The primary product of the cloned alpha-toxin gene contained a 26-amino-acid leader sequence which possessed characteristic features of a signal sequence involved in secretion. The mature alpha-toxin protein had a molecular size of 33,000 and contained only three short regions of high hydrophobicity in addition to a number of short, weakly hydrophobic regions.
摘要
测定了从金黄色葡萄球菌克隆的α-毒素基因的完整DNA序列。根据DNA序列预测的α-毒素蛋白的氨基酸序列进行了描述，并与已发表的数据进行了比较。克隆的α-毒素基因的初级产物包含一个26个氨基酸的前导序列，该序列具有参与分泌的信号序列的特征。成熟的α-毒素蛋白的分子大小为33000，除了一些短的、弱疏水区外，仅包含三个高疏水区。
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