机械通气支持下新生儿血浆β-内啡肽浓度与镇痛-肌肉松弛情况
Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation.
作者信息
Ionides S P, Weiss M G, Angelopoulos M, Myers T F, Handa R J
机构信息
Department of Pediatrics and Cell Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois.
出版信息
J Pediatr. 1994 Jul;125(1):113-6. doi: 10.1016/s0022-3476(94)70136-9.
We evaluated the effects of pancuronium and opiates on plasma beta-endorphin concentrations in 25 infants supported by mechanical ventilation. Infants receiving opiate were randomly assigned to receive either fentanyl or morphine. There was no change in beta-endorphin concentrations after administration of pancuronium, whereas both fentanyl and morphine reduced beta-endorphin concentrations by approximately 60%.
我们评估了泮库溴铵和阿片类药物对25例接受机械通气的婴儿血浆β-内啡肽浓度的影响。接受阿片类药物治疗的婴儿被随机分配接受芬太尼或吗啡。给予泮库溴铵后β-内啡肽浓度没有变化，而芬太尼和吗啡均使β-内啡肽浓度降低了约60%。
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