Uotila J T, Kirkkola A L, Rorarius M, Tuimala R J, Metsä-Ketelä T
Department of Gynecology and Obstetrics, Tampere University, Finland.
Free Radic Biol Med. 1994 May;16(5):581-90. doi: 10.1016/0891-5849(94)90058-2.
Plasma and cerebrospinal fluid total peroxyl radical-trapping antioxidative parameter (TRAP) and the main antioxidant components of TRAP (vitamin E, ascorbic acid, uric acid, protein sulfhydryl groups, and the unidentified antioxidant proportion) were analyzed in 11 preeclamptic parturients, 9 healthy parturients with an uncomplicated pregnancy, and 10 healthy nonpregnant women. In addition, the possible effects of ongoing labor were studied in 10 healthy parturients. The samples of plasma and cerebrospinal fluid (CSF) were collected at cesarean section (pregnant women) or minor surgical procedure (nonpregnant women). Normal pregnancy or ongoing labor induced no significant changes in total TRAP, as compared with nonpregnant women, but significant changes in the percentage contributions of individual antioxidants were noted in plasma and CSF. In preeclampsia, a significant increase in TRAP was noted in both plasma and CSF. This increase was mainly due to an increased proportion of uric acid and unidentified antioxidants in plasma samples, and an increased proportion of unidentified antioxidants in CSF. The concentration of CSF ascorbic acid was decreased in preeclampsia, and a negative correlation between CSF ascorbic acid and blood pressure was observed.
对11例先兆子痫产妇、9例妊娠过程无并发症的健康产妇及10例健康未孕女性的血浆和脑脊液总过氧自由基捕获抗氧化参数（TRAP）及其TRAP的主要抗氧化成分（维生素E、抗坏血酸、尿酸、蛋白质巯基及未明确的抗氧化成分比例）进行了分析。此外，还对10例健康产妇正在分娩过程中的可能影响进行了研究。血浆和脑脊液样本于剖宫产时（孕妇）或小型外科手术时（未孕女性）采集。与未孕女性相比，正常妊娠或正在分娩过程中总TRAP无显著变化，但血浆和脑脊液中各抗氧化成分的贡献百分比有显著变化。先兆子痫时，血浆和脑脊液中的TRAP均显著升高。这种升高主要是由于血浆样本中尿酸和未明确抗氧化成分的比例增加，以及脑脊液中未明确抗氧化成分的比例增加。先兆子痫时脑脊液中抗坏血酸浓度降低，且观察到脑脊液抗坏血酸与血压呈负相关。
