Warfield A T, Smallman L A
Department of Pathology, Medical School, University of Birmingham, Edgbaston.
J Clin Pathol. 1994 Apr;47(4):362-4. doi: 10.1136/jcp.47.4.362.
A case of simultaneous, bilateral pleomorphic adenoma of the parotid glands following irradiation to the head and neck for childhood Hodgkin's disease is presented. The tumour on the side given the highest radiation exposure contained so-called tyrosine rich crystalloids (TRCs). Simultaneous salivary gland neoplasms are rare; TRCs are also an unusual finding. Simultaneous pleomorphic adenomas with TRCs confined to one tumour have never been described, and any association between TRCs and irradiation has never been commented on. The precise nature of the TRCs remains obscure. Their unilateral distribution in this case supports the hypothesis that local factors are more important in their formation than systemic factors. In conjunction with other published work, this provides circumstantial evidence that irradiation may predispose to TRC deposition.
本文报告一例儿童霍奇金病患者头颈部放疗后双侧腮腺同时发生多形性腺瘤的病例。接受最高辐射剂量一侧的肿瘤含有所谓的富含酪氨酸晶体（TRCs）。同时发生的涎腺肿瘤很少见；TRCs也是一种不寻常的发现。局限于一个肿瘤的同时性多形性腺瘤伴TRCs从未被描述过，并且TRCs与放疗之间的任何关联也从未被提及。TRCs的确切性质仍不清楚。它们在该病例中的单侧分布支持了这样一种假说，即局部因素在其形成中比全身因素更重要。结合其他已发表的研究，这提供了间接证据表明放疗可能易导致TRC沉积。
