Edelman R R, Siewert B, Darby D G, Thangaraj V, Nobre A C, Mesulam M M, Warach S
Department of Radiology, Beth Israel Hospital, Boston, MA 02215.
Radiology. 1994 Aug;192(2):513-20. doi: 10.1148/radiology.192.2.8029425.
To create qualitative maps of cerebral blood flow (CBF) with the EPISTAR (echo-planar imaging and signal targeting with alternating radio frequency) technique.
The EPISTAR technique was performed in a pig model of hypercapnia and then tested in 26 volunteers by using various paradigms for cortical activation. Echo-planar images were acquired with and without use of a radio-frequency inversion pulse applied to inflowing arterial spins. A qualitative map of CBF was then created by subtracting the image obtained without the radio-frequency pulse from that obtained with the radio-frequency pulse.
Progressively more distal portions of the tagged vessels were seen as the inflow time was lengthened until cortical enhancement was seen for inflow times of approximately 1 second or longer. Signal intensity increases from rest to sensorimotor activation ranged from 13% to 193%. CBF changes in the motor strip, primary visual cortex, and the motor area for eye movements were well localized to the cortical gray matter ribbon.
The EPISTAR technique is a rapid, noninvasive means for creating qualitative maps of CBF.
