Molenda R, Szrzedziński J
Szpitala Wojewódzkiego im. J. Sniadeckiego, Białymstoku.
Wiad Lek. 1994 Jan-Feb;47(1-2):70-2.
An 18-year-old woman treated in an internal medicine department for heart complaints took clandestinely a high dose of verapamil of unknown origin. She was transferred with block grade III and blood pressure fall to the Department of Cardiology, Province Hospital, where she came with severe cardiogenic+ shock. Resuscitation--electric stimulation (external and then endocavitary), heart massage, artificial ventilation, and the drugs used (orciprenaline, atropine, dopamine, calcium)--was unsuccessful, since despite the bioelectrically effective stimulation myocardial contraction were not achieved, which was probably due to deficit of calcium necessary for activation of contractile elements in muscle fibres. The toxicological investigation demonstrated verapamil (together with its metabolites) in the blood (6 micrograms/ml) and in the liver (42 micrograms/g of tissue).
一名因心脏不适在内科接受治疗的18岁女性偷偷服用了一剂来源不明的高剂量维拉帕米。她因三度房室传导阻滞和血压下降被转至省立医院心脏病科，入院时已处于严重的心源性休克状态。复苏措施——电刺激（体外刺激，随后进行心腔内刺激）、心脏按压、人工通气以及所使用的药物（奥西那林、阿托品、多巴胺、钙剂）均未成功，因为尽管电刺激在生物电方面有效，但仍未实现心肌收缩，这可能是由于激活肌纤维收缩元件所需的钙缺乏所致。毒理学调查显示，血液（6微克/毫升）和肝脏（42微克/克组织）中存在维拉帕米（及其代谢产物）。
