Andersson M, Michel L, Llull J B, Pipkorn U
Department of Otorhinolaryngology, University Hospital, Lund, Sweden.
Allergy. 1994 Apr;49(4):242-5. doi: 10.1111/j.1398-9995.1994.tb02656.x.
Complement is a system of functionally linked serum proteins that interact to exert biologic effects in inflammatory and immunologic processes. As part of a larger study with a potential topical antiallergic drug, we measured C3a des Arg and C5a des Arg in 13 patients with seasonal allergic rhinitis and in five nonatopic controls after placebo treatment. After 1 week of placebo treatment, a nasal allergen challenge with increasing doses of pollens was performed in both allergic subjects and controls. A symptom score method was used, and in returned nasal lavage fluid, the activity of C3a des Arg and C5a des Arg was measured. We found that allergen challenge in the allergic subjects induced nasal symptoms concomitantly with increased levels of C3a des Arg and C5a des Arg (P < 0.05). No increases either in symptoms or in the very low base-line levels of C3a des Arg and C5a des Arg were observed in the nonallergic controls. We conclude that the activation of the complement cascade is one part of the vasculature exudative response during the immediate allergic reaction in the upper airways. Because of their biologic potency, these proteins may be an essential part of the exudative response which perpetuates the ongoing inflammatory reaction.
补体是一组功能相关的血清蛋白系统，它们相互作用，在炎症和免疫过程中发挥生物学效应。作为一项关于一种潜在局部抗过敏药物的更大规模研究的一部分，我们在13例季节性变应性鼻炎患者和5例非特应性对照者接受安慰剂治疗后，检测了C3a去精氨酸产物和C5a去精氨酸产物。在安慰剂治疗1周后，对变应性受试者和对照者均进行了递增剂量花粉的鼻过敏原激发试验。采用症状评分法，并检测回收的鼻灌洗液中C3a去精氨酸产物和C5a去精氨酸产物的活性。我们发现，变应性受试者的过敏原激发试验在诱导鼻部症状的同时，C3a去精氨酸产物和C5a去精氨酸产物水平升高（P<0.05）。在非变应性对照者中，未观察到症状增加或C3a去精氨酸产物和C5a去精氨酸产物的极低基线水平升高。我们得出结论，补体级联反应的激活是上呼吸道速发型过敏反应期间血管渗出反应的一部分。由于这些蛋白的生物学活性，它们可能是使正在进行的炎症反应持续存在的渗出反应的重要组成部分。
