Hansen L G, Byerly C S, Metcalf R L, Bevill R F
Am J Vet Res. 1975 Jan;36(1):23-6.
A commercial polychlorinated biphenyl (PCB) mixture containing 42% chlorine by weight was fed at the dose level of 20 ppm to 3rd-litter sows throughout gestation and nursing. Treated sows differed significantly (0.05% level) from control sows in the number of live pigs they farrowed. Treated sows also had more mummified fetuses. Performance of live-born pigs was not affected by feeding PCB to the sows during nursing. Pathologic changes in the sows included hypertrophy of liver and erosion of stomach. Two treated sows, 1 of which did not conceive, had signs of extensive chronic septicemia. Slight atrophy of spleen and thyroid gland was observed in pigs from treated sows. Blood and tissue residues of PCB were less than 0.5 ppm in both sows and pigs, but the relative amounts of PCB components varied among sows and pigs, as well as among tissues. Fat concentrations of total PCB in sows ranged from 4 to 20 ppm and those of component residues varied from 0 to 60 ppm.
一种按重量计含42%氯的商业多氯联苯（PCB）混合物，在整个妊娠期和哺乳期以20 ppm的剂量水平投喂给第三胎母猪。经处理的母猪所产活猪数量与对照母猪有显著差异（0.05%水平）。经处理的母猪还产出了更多的木乃伊化胎儿。哺乳期给母猪投喂PCB对出生仔猪的生长性能没有影响。母猪的病理变化包括肝脏肥大和胃糜烂。两只经处理的母猪，其中一只未受孕，出现了广泛的慢性败血症迹象。在经处理母猪所产仔猪中观察到脾脏和甲状腺略有萎缩。母猪和仔猪血液及组织中的PCB残留量均低于0.5 ppm，但PCB各成分的相对含量在母猪和仔猪之间以及不同组织之间有所不同。母猪体内总PCB的脂肪浓度范围为4至20 ppm，各成分残留浓度范围为0至60 ppm。
