Török P, Weber L W
Arch Environ Contam Toxicol. 1981;10(3):289-96. doi: 10.1007/BF01055630.
14C-2,4',5-trichlorobiphenyl (test series A) and a laboratory mixture of 14C-PCBs, which in addition to 2,4',5-trichlorobiphenyl, contained dichlorobiphenyl and other trichlorobiphenyl isomers (test series B), were administered orally to pregnant mice on the 13th, 15th and 17th day post conceptionem (p.c.), respectively. The development of the fetuses was accompanied by increasing activity concentrations and changes in the distribution patterns of the radioactive PCBs (and/or metabolites). In either test series, one day after administration the 18-day old fetus showed approximately a 2.5 times higher activity concentration than the fetus of an earlier developmental stage (14th day p.c.). Considering the weight gain, the quantity of activity per fetus increased almost tenfold. PCBs were concentrated only in the intestine of the terminal fetus, probably because of an increased intake of PCB-containing amniotic fluid. The affinity of the PCBs, especially of the 2,4',5 trichlorobiphenyl, to lipids, and the increasing lipid content of the fetal tissue may offer an additional explantation of the increase in activity concentration during the fetal development.
14C - 2,4',5 - 三氯联苯（测试系列A）以及一种14C - 多氯联苯的实验室混合物（除2,4',5 - 三氯联苯外，还含有二氯联苯和其他三氯联苯异构体，测试系列B），分别在受孕后第13天、第15天和第17天经口给予怀孕小鼠。随着胎儿发育，放射性多氯联苯（和/或代谢物）的活度浓度增加且分布模式发生变化。在任一测试系列中，给药一天后，18日龄胎儿的活度浓度比发育早期（受孕第14天）的胎儿高约2.5倍。考虑到体重增加，每个胎儿的活度量几乎增加了十倍。多氯联苯仅在足月胎儿的肠道中浓缩，这可能是由于含多氯联苯羊水的摄入量增加所致。多氯联苯，尤其是2,4',5 - 三氯联苯对脂质的亲和力以及胎儿组织中脂质含量的增加，可能为胎儿发育过程中活度浓度的增加提供了另一种解释。
