STEM，一种与e变异表型hrS-（Rh：-18，-19）和hrB-（Rh：-31，-34）相关的新型低频Rh抗原。

STEM, a new low-frequency Rh antigen associated with the e-variant phenotypes hrS-(Rh: -18, -19) and hrB-(Rh: -31, -34).

作者信息

Marais I, Moores P, Smart E, Martell R

机构信息

Provincial Laboratory for Tissue Immunology, Cape Town, South Africa.

出版信息

Transfus Med. 1993 Mar;3(1):35-41. doi: 10.1111/j.1365-3148.1993.tb00102.x.

DOI:10.1111/j.1365-3148.1993.tb00102.x

PMID:8038895

Abstract

The new low-frequency antigen STEM was identified when a Cape coloured woman with an unknown antibody in her plasma (which agglutinated the red cells of her husband and a minority of other individuals) gave birth to a baby suffering mildly from haemolytic disease of the new-born. Most, but not all, examples of anti-STEM distinguish different strengths of STEM antigen on the red cells of different people; the different strengths are inherited. Family studies established that STEM was inherited as a Mendelian dominant character. STEM subdivides hrS-(Rh: -18, -19) and hrB- (Rh: -31, -34) red cells into two types: STEM+ and STEM-. The manually calculated lod score for STEM being associated with the Rh system is 3.91 and LIPED calculated lod score 4.35. The International Society of Blood Transfusion has allocated STEM the Rh number 49.

摘要

新的低频抗原STEM是在一名开普有色人种女性分娩出一名患有轻度新生儿溶血病的婴儿时被发现的，该女性血浆中有一种未知抗体（能凝集其丈夫及少数其他人的红细胞）。大多数（但并非全部）抗STEM实例能区分不同人红细胞上不同强度的STEM抗原；不同强度是可遗传的。家系研究表明，STEM作为孟德尔显性性状遗传。STEM将hrS-（Rh：-18，-19）和hrB-（Rh：-31，-34）红细胞细分为两种类型：STEM+和STEM-。手动计算得出STEM与Rh系统相关的连锁值为3.91，LIPED计算得出的连锁值为4.35。国际输血协会已将Rh编号49分配给STEM。