Amemiya M, Ueno M, Osono M, Masuda T, Kinoshita N, Nishida C, Hamada M, Ishizuka M, Takeuchi T
Institute for Chemotherapy, M. C. R. F. Shizuoka, Japan.
J Antibiot (Tokyo). 1994 May;47(5):536-40. doi: 10.7164/antibiotics.47.536.
Cytostatin has been identified as a novel inhibitor of cell adhesion to components of extracellular matrix (ECM) in cultured broth of Streptomyces sp. MJ654-NF4. Though cytostatin did not inhibit EL-4 cell adhesion to ECM components such as laminin and fibronectin; it inhibited the adhesion of B16 melanoma cells to laminin and collagen type IV but not to fibronectin. It exhibited antimetastatic activity on B16 melanoma cells in mice. The cytotoxicity of cytostatin are also reported.
细胞抑制素已被鉴定为链霉菌属MJ654-NF4培养液中一种新型的细胞与细胞外基质（ECM）成分黏附的抑制剂。尽管细胞抑制素不抑制EL-4细胞与层粘连蛋白和纤连蛋白等ECM成分的黏附；但它抑制B16黑色素瘤细胞与层粘连蛋白和IV型胶原的黏附，而不抑制其与纤连蛋白的黏附。它在小鼠体内对B16黑色素瘤细胞表现出抗转移活性。细胞抑制素的细胞毒性也有报道。
