[The effect of prostaglandin E2 on chemiluminescent activity of peritoneal exudate cells of intact animals and animals, inoculated with various materials].

Changes in the normal cellular content and chemiluminescence (CL) activity of peritoneal exudate cells at the first hours after intraperitoneal injection of thioglycollate, casein, mineral oil and BCG were studied, as well as the influence of PGE2 on the CL activity of such cells. It has been shown, that 3-5 hours after intraperitoneal inoculation with these materials, independently from the type of the material used, the enrichment of peritoneal cell population with neutrophils, up to 90% or more, takes place. PGE2 induced the significant inhibition of the CL activity of peritoneal exudate cells from the animals, injected with thioglycollate and BCG, but did not influence the CL activity of peritoneal cells from the intact animals and animals injected with casein. The possible connection of these differences with the level of PGE2 receptors expression on the intact and stimulated peritoneal cells is discussed.