精神分裂症患者体重变化的临床关联

Clinical correlates of body weight changes in schizophrenia.

作者信息

Lawson W B, Karson C N

机构信息

Psychiatry Service, John L. McClellan Memorial Veterans Hospital, North Little Rock, Arkansas.

出版信息

J Neuropsychiatry Clin Neurosci. 1994 Spring;6(2):187-8. doi: 10.1176/jnp.6.2.187.

DOI:10.1176/jnp.6.2.187

PMID:8044044

Abstract

Body weight was examined in chronic schizophrenic patients. Underweight medicated patients had normal ventricular brain ratios (VBRs) on CT. Overweight patients had both normal and abnormal VBRs. Weight decreased during neuroleptic withdrawal; caloric intake and weight increased when neuroleptics were reinstituted. Weight gain on neuroleptics correlated with symptom improvement independent of VBR or gender. Weight changes and psychosis in schizophrenia may be mediated by similar neurochemical systems.

摘要

对慢性精神分裂症患者的体重进行了检查。体重偏轻的服药患者在CT上的脑室脑比率（VBR）正常。超重患者的VBR既有正常的也有异常的。在停用抗精神病药物期间体重下降；重新使用抗精神病药物时热量摄入和体重增加。服用抗精神病药物导致的体重增加与症状改善相关，与VBR或性别无关。精神分裂症中的体重变化和精神病可能由相似的神经化学系统介导。