Bundey S, Alam H
Sub-Department of Clinical Genetics, University of Birmingham, UK.
Eur J Hum Genet. 1993;1(3):206-19. doi: 10.1159/000472414.
A 5-year prospective study of 4,934 children of different ethnic groups has demonstrated a 3-fold increase of postneonatal mortality and childhood morbidity in the offspring of consanguineous Pakistani parents. Most of these families contained more than one consanguineous union, resulting in a mean inbreeding coefficient for their children of 0.0686. It is estimated that 60% of the mortality and severe morbidity of this group of children could be eliminated if inbreeding ceased. However consanguinity is much favoured in this minority group, and health education will have to be carefully and sensitively handled.
一项针对4934名不同种族儿童的5年前瞻性研究表明，巴基斯坦近亲结婚父母的后代中，新生儿后期死亡率和儿童发病率增加了两倍。这些家庭中的大多数都有不止一个近亲婚姻，其子女的平均近亲系数为0.0686。据估计，如果停止近亲结婚，这群儿童60%的死亡率和严重发病率可以消除。然而，这个少数群体非常倾向于近亲结婚，因此必须谨慎、敏感地开展健康教育。
